| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Campbell Scott | Mark Usher |
| Paul Sparks | Thomas Yates |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Joel Kinnaman | Will Conway |
| Dominique McElligott | Hannah Conway |
| Boris McGiver | Tom Hammerschmidt |
| Korey Jackson | Sean Jeffries |
| Larry Pine | Bob Birch |
| Jayne Atkinson | Catherine Durant |
| Curtiss Cook | Terry Womack |
| Colm Feore | Ted Brockhart |
| Lars Mikkelsen | Viktor Petrov |
| James Martinez | Alex Romero |
| Damian Young | Aidan Macallan |
| Kate Lyn Sheil | Lisa Williams |
| Scott Whitehurst | Randy Watts |
| Darlesia Cearcy | Simone Murphy |
| Kristen Sieh | Kelsey |
| Michael Siberry | David Rasmussen |
| Adam Donshik | Jordan Sadowsky |
| Malcolm Madera | Eric Rawlings |
| Finn Douglas | Charlie Conway |
| Mark Borkowski | Ted Barnes |
| Michael Gabel | Chief Justice |
| David Abrams | Reporter |
| Rasool J'Han | Reporter
(as Rasool Jahan) |
| Laura Chaneski | Reporter |
| Nini Le Huynh | Claire's Assistant |
| Allen Fawcett | Pilot |
| Fred Arsenault | Co-Pilot |
| Maria Konstantinidis | Tour Guest |
| Sarah Laine Smith | Makeup Artist |
| Gary Ayash | White House Press Corp Reporter
(uncredited) |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Elliott Grey | Congressman #2
(uncredited) |
| Gina Jun | Staff
(uncredited) |
| Gemma McIlhenny | Congresswoman
(uncredited) |
| Ryan A. Phillips | Drug Dealer
(uncredited) |