| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Campbell Scott | Mark Usher |
| Paul Sparks | Thomas Yates |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Joel Kinnaman | Will Conway |
| Dominique McElligott | Hannah Conway |
| Boris McGiver | Tom Hammerschmidt |
| Korey Jackson | Sean Jeffries |
| Colm Feore | Ted Brockhart |
| Kate Lyn Sheil | Lisa Williams |
| Wendy Moniz | Laura Moretti |
| Reed Birney | Donald Blythe |
| James Martinez | Alex Romero |
| Damian Young | Aidan Macallan |
| Malcolm Madera | Eric Rawlings |
| Barbara Rosenblat | Louise Talbert
(as Barbara Rosenblatt) |
| Kayla Blake | Kerry Kuilima |
| Kelly McAndrew | Susan Newman |
| Andy Murray | Airman Webson |
| Alexis Nichole Smith | Angela |
| Joe Scarborough | Joe Scarborough |
| Mika Brzezinski | Mika Brzezinski |
| Donny Deutsch | Donny Deutsch |
| Kasie Hunt | Kasie Hunt |
| Luke Forbes | Secret Service Driver |
| Laura Cayouette | Woman |
| Brittney Aleah | Anti-Underwood Protester |
| Herbert Lee Frazier III | Anti-Underwood Protester |
| Dennis P. Marburger | Voter |
| Jennifer Stokes | Onlooker /
Mourner |
| Annie Bao | Anti-Underwood Protestor
(uncredited) |
| Patrick Brown | White House Server
(uncredited) |
| Gwenyth Clark | Chapter 57
(uncredited) |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Lamont Easter | Underwood Secret Service
(uncredited) |
| David Douglas Johnston | White House Protester
(uncredited) |
| Jeffrey Mowery | Herald Photographer
(uncredited) |
| Carly Tamborski | Anti-Underwood Protester
(uncredited) |