| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Paul Sparks | Thomas Yates |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Joel Kinnaman | Will Conway |
| Dominique McElligott | Hannah Conway |
| Korey Jackson | Sean Jeffries |
| Jayne Atkinson | Catherine Durant |
| Colm Feore | General Brockhart |
| Dan Ziskie | Jim Matthews |
| Damian Young | Aidan Macallan |
| William Hill | Ken Caswell |
| Reed Birney | Donald Blythe |
| Andrew Polk | Harry Marshall |
| James Martinez | Alex Romero |
| Kenneth Tigar | Walter Doyle |
| Lee R. Sellars | Governor Olmstead
(as Lee Sellars) |
| Steve Coulter | Mitch Scanlon |
| Paton Ashbrook | Bridget Cohen |
| Sophie von Haselberg | Tanya Benson |
| Amanda Warren | Jenna Perkins |
| Alex Zuko | Rick Sussman |
| Ken Barnett | Stephen Haines |
| Finn Douglas | Charlie Conway |
| Bret Baier | Bret Baier |
| Brannon Cross | Reg |
| Alphie Hyorth | Mayor Adalardi |
| David Bishins | Secretary of Homeland Security |
| Kathleen Mary Carthy | Moderator |
| Felix Stevenson | White House Steward |
| Estes Tarver | Driver |
| Robert Beard | Telecom Head |
| Kelly Mumme | Reporter |
| Gary Ayash | White House Press Corp Reporter
(uncredited) |
| Matthew Bernard | Press
(uncredited) |
| Sean M. Brown | Lawyer
(uncredited) |
| Charles D. Clark | Executive Campaign Staff
(uncredited) |
| Lawrence Derx | Catherine Durant Security
(uncredited) |
| Justin Doescher | Frank's Secret Service
(uncredited) |
| Lamont Easter | Underwood Secret Service
(uncredited) |
| Mark Falvo | Congressman
(uncredited) |
| Gina Jun | Staff
(uncredited) |
| Randy Thomas Lindsay | Patron
(uncredited) |
| George Ludden | Congressman
(uncredited) |
| Jose L. Penaranda | Governor of Nevada
(uncredited) |
| Tatyana N. Pokrovskaya | Government Type
(uncredited) |
| Vanessa Quinlivan | Hotel Employee
(uncredited) |
| Andy Rivera | Guatemalan Foreign Minister
(uncredited) |
| Bob Singer | Governor of Louisiana
(uncredited) |
| Jennifer Stokes | Onlooker /
Mourner
(uncredited) |
| Peter Sweet | Politician
(uncredited) |
| Gary Lee Vincent | Congressman
(uncredited) |
| Marla Aaron Wapner | Reporter at Bar
(uncredited) |