| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Mahershala Ali | Remy Danton |
| Molly Parker | Jackie Sharp |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Boris McGiver | Tom Hammerschmidt |
| Paul Sparks | Thomas Yates |
| Joel Kinnaman | Will Conway |
| Dominique McElligott | Hannah Conway |
| Colm Feore | General Brockhart |
| Damian Young | Aidan Macallan |
| Andrew Polk | Harry Marshall |
| Jeremy Holm | Nathan Green |
| Kathleen Chalfant | Margaret Tilden |
| Wendy Moniz | Laura Moretti |
| Jefferson White | Joshua Masterson |
| Mercedes Herrero | Director of National Intelligence |
| John Rue | CIA Director |
| Julian Gamble | Chairman of the Joint Chiefs |
| C.J. Wilson | Agent Lasker
(as CJ Wilson) |
| Alfredo Narciso | Agent Holbrooke |
| Andre Ware | NSA Director |
| David Bishins | Secretary of Homeland Security |
| Kim Ramirez | Agent March |
| Sean C. Graham | James Miller
(as Sean Graham) |
| Jennifer Leigh Mann | Caroline Miller |
| Alie Urquhart | Melissa Miller |
| Dana Healey | George Walleck |
| Finn Douglas | Charlie Conway |
| Ben VanderMey | Zachary Hawthorne |
| Amr El-Bayoumi | Ibrahim Halabi |
| Gwen Ifill | Gwen Ifill |
| Anntoinette Johnson | Gwen Ifill's Producer |
| Greg Lang | Military Aide |
| Craig Newkirk | NSA Agent #1 |
| Lane Carlock | Herald Reporter |
| Anthony Reynolds | Herald Lawyer |
| Draaco Aventura | WH Press Corps |
| Gregory Divers | White House Press Corps |
| Andre Faulcon | Conway Security |
| Michel Gill | President Garrett Walker |
| Jeffrey Klemmer | Secret Service Agent |
| Gretchen Koerner | NSA Agent 2 |
| Kevin D. Benton | Government Type
(uncredited) |
| Lauren Cox | Claire's Secret Service
(uncredited) |
| Justin Doescher | Frank Underwood Security
(uncredited) |
| Lamont Easter | Underwood Secret Service
(uncredited) |
| Barbara Edwards | Washington Herald Press
(uncredited) |
| Lindsay Dyan Epp | White House Press
(uncredited) |
| Mark Falvo | White House Press Corps
(uncredited) |
| Nick Madrick | SS Agent #1
(uncredited) |
| Jay McCord | White House Press Corps
(uncredited) |
| Antoinette Montgomery | White House Press Corps
(uncredited) |
| Hiten D. Patel | White House Staffer
(uncredited) |
| Babs Proller | Clerk of Courts
(uncredited) |
| Gonzalo Vargas | Herald Reporter
(uncredited) |