| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Paul Sparks | Thomas Yates |
| Joel Kinnaman | Will Conway |
| Dominique McElligott | Hannah Conway |
| Jayne Atkinson | Catherine Durant |
| Reed Birney | Donald Blythe |
| Colm Feore | General Brockhart |
| Andrew Polk | Harry Marshall |
| LisaGay Hamilton | Celia Jones |
| John C. Vennema | Senator Sheer |
| Doug Barron | Senator Baker |
| Finn Douglas | Charlie Conway |
| Donnie Kehr | Adam Gould |
| Linda Atkinson | Madam Secretary |
| Susanne Arrington | Tennessee Chair |
| Gilbert Cruz | Texas Chair |
| Randall Taylor | Alabama Chair |
| MauraClaire Harford | Alaska Chair
(as Maura Claire Harford) |
| Demetria Bailey | California Chair
(as Demetria Joyce Bailey) |
| Alan Wade | Delaware Chair |
| Ann Harada | Hawaii Chair |
| Alan Richmond | Indiana Chair |
| Scott Lehman | Louisiana Chair |
| Jake Tapper | Jake Tapper |
| Paul Begala | Paul Begala |
| S.E. Cupp | S.E. Cupp |
| Van Jones | Van Jones |
| David Shae | Buha
(as David Moretti) |
| Susan Rome | Danny's Mother |
| Shaira Barton | Luisa's Mother |
| Tasia Grant | Reporter 1 |
| Lauren O'Quinn | Reporter 2 |
| Cynthia Steele Vance | Reporter 3 |
| Sanjay Raja | Reporter 4 |
| Kelly Miller | News Correspondent |
| Mike Lutz | Speechwriter 1 |
| Felicia Greenfield | Speechwriter 2 |
| Frank Sesno | News Anchor |
| Taylor Thomas | News Anchor |
| Lee Ordeman | News Anchor |
| Carolyn Presutti | News Anchor |
| Melanie Hastings | News Anchor |
| Jessica Kartalija | News Anchor |
| Jonathan D. Williams | News Anchor |
| Bobby Kruger | Durant's Staffer |
| Craig Galloway | Secret Service Agent |
| Katrina Clark | Sign Language Interpreter |
| Draaco Aventura | WH Press Corps
(uncredited) |
| Gary Ayash | White House Press Corp Reporter-DNC
(uncredited) |
| Kaylyn Aznavorian | Alabama Delegate
(uncredited) |
| Aldoris Bate | Delegate
(uncredited) |
| Matthew Bernard | Press
(uncredited) |
| Todd Bobenrieth | Delegate
(uncredited) |
| A.C. Bryan | College Student
(uncredited) |
| Loretta Burnette | Convention Delegate
(uncredited) |
| Stephanie Cookie Carson | Convention Delegate
(uncredited) |
| Lauren Cox | Claire's Secret Service
(uncredited) |
| Justin Doescher | Frank Underwood Security
(uncredited) |
| Melissa Dudek | White House Press Corp
(uncredited) |
| Lamont Easter | Underwood Secret Service
(uncredited) |
| Lindsay Dyan Epp | White House Press
(uncredited) |
| Mark Falvo | White House Press Corps
(uncredited) |
| Andre Faulcon | Conway Security
(uncredited) |
| Loren Fenton | Mother
(uncredited) |
| Brian Foreman | Campaign Manager
(uncredited) |
| Anne Marie Howard | Correspondent #2
(uncredited) |
| Antoinette Montgomery | White House Press Corps
(uncredited) |
| Sindy Nurse | Campaign Manager
(uncredited) |
| Tatyana N. Pokrovskaya | Democrat
(uncredited) |
| Christopher Reed | Background Player
(uncredited) |
| Heidi Segal | Delegate
(uncredited) |
| Jacalyn E. Stanley | Delegate
(uncredited) |
| Peter Sweet | Delegate and White House Reporter
(uncredited) |
| Elizabeth Thorp | Illinois Delegate
(uncredited) |
| Paul Wallis | DNC Cameraman
(uncredited) |
| Marla Aaron Wapner | News Reporter
(uncredited) |
| Jeffrey Wells | Kentucky Delegate
(uncredited) |
| John Wells | Press Corps
(uncredited) |
| Ted Williams | Cameraman
(uncredited) |