| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Derek Cecil | Seth Grayson |
| Neve Campbell | Leann Harvey |
| Boris McGiver | Tom Hammerschmidt |
| Paul Sparks | Thomas Yates |
| Dominique McElligott | Hannah Conway |
| Kim Dickens | Kate Baldwin |
| Colm Feore | General Brockhart |
| Damian Young | Aidan MacAllan |
| Sean Cullen | Senator Dean Austen |
| Larry Pine | Bob Birch |
| Curtiss Cook | Terry Womack |
| Joel Kinnaman | Will Conway |
| Ian Blackman | Casey Giallo |
| Erika Rolfsrud | Julia Melman |
| Julee Cerda | Dana Treister |
| Mark Borkowski | Ted Barnes |
| Tracy McMullan | Olivia Austen |
| Allie McCulloch | Sally |
| George R. Sheffey | Executive Director |
| Craig Newkirk | NSA Agent #1 |
| Kate Bennis | Photographer |
| Tony Senzamici | Austen's Chief of Staff |
| Suehyla El-Attar Young | Austen's Staffer
(as Suehyla El-Attar) |
| Rebecca Street | Homeless Woman |
| Anthony DeVito | Pizza Guy |
| Draaco Aventura | WH Press Corps |
| A.C. Bryan | College Student |
| Andre Faulcon | Conway Security |
| Gretchen Koerner | NSA Agent 2 |
| Jeff Moore | Restaurant Patron |
| Tatyana N. Pokrovskaya | Conway Supporter |
| Kevin Tan | Photographer's Assistant |
| John Wells | Press Corps |
| Joshua Barnes | Police Officer
(uncredited) |
| Lauren Cox | Claire's Secret Service
(uncredited) |
| Justin Doescher | Frank Underwood Security
(uncredited) |
| Lamont Easter | Underwood Secret Service
(uncredited) |
| Antoinette Montgomery | White House Press Corps
(uncredited) |
| Tim R. Worley | Congressman
(uncredited) |