| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Mahershala Ali | Remy Danton |
| Elizabeth Marvel | Heather Dunbar |
| Derek Cecil | Seth Grayson |
| Jimmi Simpson | Gavin Orsay |
| Nathan Darrow | Edward Meechum |
| Jayne Atkinson | Catherine Durant |
| Rachel Brosnahan | Rachel Posner |
| Mozhan Marnò | Ayla Sayyad |
| Benito Martinez | Hector Mendoza |
| Reed Birney | VP Donald Blythe |
| Poorna Jagannathan | Dr. Lanjawni |
| Kelly AuCoin | Gary Stamper |
| Jonathan Hogan | Justice Jacobs |
| Christina Bennett Lind | Sharon |
| Sam Freed | Paul Landry |
| Ari Melber | Ari Melber |
| Perry Bacon Jr. | Perry Bacon |
| Stephen Colbert | Stephen Colbert |
| Neal Matarazzo | Detective Pryor |
| Chris McKinney | Detective Noland |
| Olivia Luccardi | Escort |
| John Rue | CIA Director |
| Mercedes Herrero | National Security Advisor |
| Julian Gamble | Chairman of Joint Chiefs |
| Robert Poletick | Defense Secretary Davis |
| Jeffrey Voice | Colonel |
| Andrea Leigh | WH Secretary |
| William L. Thomas | WH Reporter Greg |
| Julie Mun | WH Reporter Sara |
| Tim Pabon | WH Reporter Mark |
| Staci Dickerson | WH Reporter Jess |
| Maceo Oliver | ER Doctor |
| Adam Devine | Photographer at Graveyard |
| Brittney Aleah | White House Staffer |
| Gary Ayash | White House Press Corp Reporter |
| Chrislene Bright | White House Press Corp. |
| Zionah Butler | Student |
| Steven Carino | Videographer |
| Peter Chiamardas | White House Press |
| Ben Cook | Heather Dunbar's Son |
| James Davenjay | White House Staff |
| Patricia DiZebba | Nurse |
| Justin Doescher | Frank Underwood Security |
| Catherine Duvall | Reporter |
| Lamont Easter | Underwood Secret Service |
| Lindsay Dyan Epp | White House Press |
| Mark Falvo | White House Press Corps |
| Mary-Alice Farina | White House Press Corps |
| Liam Ferguson | Press |
| Dave Ferrier | Videographer |
| Michael Garvey | Delegate |
| Shawn Gonzalez | White House Staff |
| Cynthia Kossally | Nurse |
| Joanna M. Lewis | Reporter |
| Dan Verkman | White House Press Corp |
| Jay Viera | State Police |
| Mark Vincent | Tactical Secret Service |
| Marla Aaron Wapner | WH Press Corp |