| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Wonsup Chung | Young Asian Man |
| Michael Kelly | Doug Stamper |
| Sakina Jaffrey | Linda Vasquez |
| Kristen Connolly | Christina Gallagher |
| Mahershala Ali | Remy Danton |
| Michel Gill | President Garrett Walker |
| Gerald McRaney | Raymond Tusk |
| Molly Parker | Jackie Sharp |
| Terry Chen | Xander Feng |
| Derek Cecil | Seth Grayson |
| Sam Page | Connor Ellis |
| Joanna Going | First Lady Tricia Walker |
| Mozhan Marnò | Ayla Sayyad |
| Gil Birmingham | Daniel Lanagin |
| Reg E. Cathey | Freddy |
| Larry Pine | Bob Birch |
| Curtiss Cook | Terry Womack |
| Albert Jones | Tommy Devine |
| Jeremy Bobb | Nick Henslow |
| Kenneth Tigar | Walter Doyle |
| Andrea Cirie | Lorrie Tate |
| Tanis Parenteau | Tammy |
| Michael Wingate Jones | Casino Security Specialist |
| Yan Xi | Mandarin Translator |
| Bella Chu | Chinese Woman |
| Brenda Heckert | Tusk's Secretary |
| Joshua Craig | Secret Service Agent |
| Steve 'Stevieweevie' Jones | Casino Patron |
| Dan Matteucci | Marine |
| Lynnanne Zager | Political Commercial Announcer |
| Richard Adams | Casino Attendent |
| Troy Bogdan | Casino Patron |
| Ulysses E. Campbell | Ogilvy |
| Justin Doescher | Frank Underwood Security |
| James Donahue | Walker Secret Service |
| Lamont Easter | Underwood Secret Service |
| Kevin Hunt | Underwood Secret Service |
| Tarra Denise Jackson | Office Assistant |
| Jed Lunario | White House Staff |
| Jeremy McLain | Walker Secret Service |
| Fernando A. Mico | Feng Business Associate |
| Brooke Mulkins | Stamper Staffer |
| Tom Myers | Casino Patron |
| Al Sotto | Casino Security Guard |
| Zach Steffey | Airline Counter Attendent |
| John Wells | Gambler |