| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Kate Mara | Zoe Barnes |
| Michael Kelly | Doug Stamper |
| Sakina Jaffrey | Linda Vasquez |
| Corey Stoll | Rep. Peter Russo |
| Kristen Connolly | Christina Gallagher |
| Sebastian Arcelus | Lucas Goodwin |
| Sandrine Holt | Gillian Cole |
| Nathan Darrow | Edward Meechum |
| Michel Gill | President Garrett Walker |
| Dan Ziskie | VP Matthews |
| Larry Pine | Bob Birch |
| Elizabeth Norment | Nancy Kaufberger |
| Constance Zimmer | Janine Skorsky |
| Chuck Cooper | Barney Hull |
| Rachel Brosnahan | Rachel Posner |
| Curtiss Cook | Terry Womack |
| Tawny Cypress | Carly Heath |
| PJ Landers | Bearded Man |
| Amy Tribbey | Diane |
| Kenneth Tigar | Walter Doyle |
| James Hindman | Nash Aarons |
| Andrew Kober | Joe Taminini |
| Kara Jackson | Mandy Pierce |
| Kevyn Settle | Drew Coughlin |
| David Mason | Randy Flint |
| Darla Robinson | Moderator |
| Nancy Nagrant | Press Secretary Maggie Wilson |
| Simon Feil | VP's Chief of Staff |
| Elan Noelle | Bartender - Dupont Circle Bar |
| Heather Callahan-Stevens | Legislative Aide
(uncredited) |
| Elihu Eli El | Congressman Wilkins
(uncredited) |
| Dave Ferrier | Photographer
(uncredited) |
| Chelsea Grace Fox | Dog Walker
(uncredited) |
| Tom Gambrill | Newspaper Reporter
(uncredited) |
| Brian Harrison | Reporter
(uncredited) |
| Jaci Jones | Staffer
(uncredited) |
| Micheila Leighland | Legislative Aide
(uncredited) |
| Sam McCrea | Congressional Hearing Reporter
(uncredited) |
| John Peddie | Pedestrian
(uncredited) |
| Michelle Roy | Legislative Aide
(uncredited) |
| Bob Schwartz | Press Photographer
(uncredited) |
| Monika Spruch | Guest
(uncredited) |
| Chuck Taber | Shipyard Worker
(uncredited) |
| Lawrence Whitener | Cab Driver
(uncredited) |
| Aaron Wiggins | Pedestrian
(uncredited) |