| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Kate Mara | Zoe Barnes |
| Michael Kelly | Doug Stamper |
| Corey Stoll | Rep. Peter Russo |
| Kristen Connolly | Christina Gallagher |
| Sandrine Holt | Gillian Cole |
| Boris McGiver | Tom Hammerschmidt |
| Kathleen Chalfant | Margaret Tilden |
| Nathan Darrow | Edward Meechum |
| Ben Daniels | Adam Galloway |
| Karl Kenzler | Sen. Charles Holburn |
| Francie Swift | Felicity Holburn |
| Reg E. Cathey | Freddy |
| Elizabeth Norment | Nancy Kaufberger |
| Ben Hyland | Kevin Russo |
| Daisy Tahan | Sarah Russo |
| Al Sapienza | Marty Spinella |
| Tawny Cypress | Carly Heath |
| Suzanne Savoy | Patricia Whittaker |
| Peak Kwinarian | Deputy Chair |
| Wass Stevens | Paul Capra |
| Erin Fritch | Ashley |
| Kathy McCafferty | Press Secretary |
| Curran Connor | Media Consultant |
| Michael McKenzie | Hotel Manager |
| Kianné Muschett | Reporter
(as Kianne Muschett) |
| Steve Lebens | Tilden's Assistant |
| Prairie Griffith | Protester |
| James Waters | Staffer Kid |
| Erica Chamblee | Cassandra |
| Marva Hicks | Strategist 1 |
| Maury Ginsberg | Strategist 2 |
| Maureen Kerrigan | Strategist 3 |
| Kevin Murray | Strategist 4 |
| Mary Lee Adams | Russo Intern
(uncredited) |
| Victoria Anastasi | Francis Staffer
(uncredited) |
| Laura Avnaim | Pedestrian
(uncredited) |
| Lori Bedsole | Union Protestor
(uncredited) |
| Yuri Chernykh | Union Protestor
(uncredited) |
| Jonathan W. Colby | Slugline Employee
(uncredited) |
| Edward Daniels | Disc Jockey
(uncredited) |
| Bruce Allen Dawson | Union Protest Leader
(uncredited) |
| Jodi Dawson | CWI Staffer
(uncredited) |
| Azize Erim | Party Patron
(uncredited) |
| Armando Gutierrez | CWI Staffer
(uncredited) |
| Doug Henderson | Union Protester
(uncredited) |
| Jan Johns | Associate
(uncredited) |
| Candice 'CJ' Johnson | Slugline
(uncredited) |
| Mc Jones | Martin
(uncredited) |
| Cristen Kennedy | Underwood Caterer
(uncredited) |
| Marcus LaRon | Precision Driver
(uncredited) |
| Micheila Leighland | Gala VIP
(uncredited) |
| James Mahony | Bartender
(uncredited) |
| Stephanie McIntyre | Nurse Sophia Vemratti
(uncredited) |
| Anita Moore | Reporter
(uncredited) |
| Peter Muggleworth | Capitol Police
(uncredited) |
| Jose Luis Munoz | Union Protester
(uncredited) |
| Christina Ritter | Office Staffer
(uncredited) |
| Elena Schick | TV Reporter
(uncredited) |
| Bob Schwartz | Photographer
(uncredited) |
| Marla Aaron Wapner | TV Reporter
(uncredited) |
| LaToya Ward | CWI Staffer
(uncredited) |
| April Whatley | Reporter
(uncredited) |