| Richard Belzer | John Munch |
| Andre Braugher | Frank Pembleton |
| Reed Diamond | Mike Kellerman |
| Michelle Forbes | Dr. Julianna Cox |
| Peter Gerety | Stuart Gharty |
| Clark Johnson | Meldrick Lewis
(credit only) |
| Yaphet Kotto | Al Giardello |
| Toni Lewis | Terri Stivers |
| Kyle Secor | Tim Bayliss
(credit only) |
| Jon Seda | Paul Falsone |
| Callie Thorne | Laura Ballard |
| Victor Anthony | Pedro Velez |
| Melvin L. Cauthen | Commuter |
| Bruce Elliott | Cyrus Sink
(as Bruce Elliot) |
| Zeljko Ivanek | ASA Ed Danvers |
| Avery Kidd Waddell | Rock Rock |
| Bob Lau | Process Server |
| Clayton LeBouef | Col. George Barnfather |
| Ellen McElduff | Billie Lou Hatfield |
| John Opladen | Father Walcott |
| Jonathan Orcutt | Stephen Zaymore |
| Michael Peña | Luis Carrenza
(as Michael Anthony Pena) |
| Doug Roberts | Donald Tochterhagen |
| Leslie Silva | Sister Dyanne Attwood |
| Jay Spadaro | Officer Salerno |
| Monica Trombetta | Janine Falzone |
| Rozwill Young | Swami Ajay Prabhunanda |
| Sharon Ziman | Naomi |
| Kirk Alexander | Stink
(uncredited) |
| Nick Olcott | Father Klaske
(uncredited) |
| John Orofino | Officer Hoskins
(uncredited) |
| Karl Otter | Crime Lab Photographer
(uncredited) |