| Richard Belzer | John Munch |
| Andre Braugher | Frank Pembleton |
| Reed Diamond | Mike Kellerman |
| Michelle Forbes | Dr. Julianna Cox |
| Peter Gerety | Stuart Gharty
(credit only) |
| Clark Johnson | Meldrick Lewis |
| Yaphet Kotto | Al Giardello |
| Kyle Secor | Tim Bayliss |
| Jon Seda | Paul Falsone |
| Callie Thorne | Laura Ballard |
| Alison Folland | Grace Rivera |
| Toni Lewis | Terri Stivers |
| Hazelle Goodman | Georgia Rae Mahoney |
| Ami Brabson | Mary Pembleton |
| Helen Carey | Maggie Conroy |
| Granville Adams | Officer Jeff Westby |
| Chris Fischer | Matt Northrup
(as Christopher James Fischer) |
| Sean Whitesell | Dr. Eli Devilbiss |
| Susan Allenback | Dr. Lindsay Porter
(as Susan Allenbach) |
| Stephen Angus | Alex Carew |
| Rick Holloway | Ted Ganz |
| Billie Jackson | Lt. Kate McClendon |
| Katrina Owens | Angela Tripp |
| Charles Pendelton | Manny Korman |
| Holly Twyford | Ivy Kiriakis |
| H. Michael Walls | Anders Corolli |
| Dale Guy Madison | Male Nurse
(uncredited) |