| Richard Belzer | John Munch |
| Andre Braugher | Frank Pembleton |
| Reed Diamond | Mike Kellerman |
| Michelle Forbes | Dr. Julianna Cox |
| Clark Johnson | Meldrick Lewis |
| Yaphet Kotto | Al Giardello |
| Melissa Leo | Kay Howard |
| Max Perlich | J.H. Brodie |
| Kyle Secor | Tim Bayliss |
| Melvin Van Peebles | Bennett Jackson |
| Kristin Rohde | Sgt. Sally Rogers |
| Barry Levinson | Self |
| Zite Bidanie | Motorist
(as Zité Bidanie) |
| La Kisha Davis | Alice Duncan |
| Rich Gordon | Stan Rogan |
| Europe Harmon | Levon Carter |
| Walt MacPherson | Roger Gaffney |
| Ami Brabson | Mary Pembleton
(archive footage) (uncredited) |
| Tim Carr | Police Cadet
(uncredited) |
| Isabella Hofmann | Megan Russert
(archive footage) (uncredited) |
| Toni Lewis | Terri Stivers
(archive footage) (uncredited) |
| Chuck Paris | Baltimore Police Officer
(uncredited) |
| Ralph Tabakin | M.E. Dr. Scheiner
(archive footage) (uncredited) |
| Judy Thornton | Judy
(uncredited) |