| Richard Belzer | John Munch |
| Andre Braugher | Frank Pembleton |
| Reed Diamond | Mike Kellerman
(credit only) |
| Isabella Hofmann | Megan Russert |
| Clark Johnson | Meldrick Lewis |
| Yaphet Kotto | Al Giardello |
| Melissa Leo | Kay Howard |
| Kyle Secor | Tim Bayliss |
| Marcia Gay Harden | Joan Garbarek |
| Gary Basaraba | Paul Garbarek |
| Sean Whitesell | Dr. Eli Devilbiss |
| Bari Biern | Nurse |
| Simon Bennett | Donny Porton |
| Terry Hinz | William Loftus |
| Andreas Kraemer | Tommy Porton |
| Sharon Ziman | Naomi |
| Steve Harper | Crime Technician
(uncredited) |
| Mandy Patinkin | Dr. Jeffrey Geiger
(uncredited) |
| Stephen Francis Quinn | Patrick Garbarek
(uncredited) |