| Daniel Baldwin | Beau Felton |
| Richard Belzer | John Munch |
| Andre Braugher | Frank Pembleton |
| Clark Johnson | Meldrick Lewis |
| Yaphet Kotto | Al Giardello |
| Melissa Leo | Kay Howard |
| Jon Polito | Steve Crosetti |
| Kyle Secor | Tim Bayliss |
| Ned Beatty | Stanley 'The Big Man' Bolander |
| Zeljko Ivanek | ASA Ed Danvers |
| Wendy Hughes | Dr. Carol Blythe, M.E. |
| Jennifer Harmon | Alison Ashley |
| Lee Tergesen | Officer Chris Thormann |
| Edie Falco | Eva Thormann |
| Sean Whitesell | Dr. Eli Devilbiss |
| Tim Caggiano | Orville Warren |
| David DeBoy | Rufus Bond |
| Mojo Gentry | Alfred Smith |
| Julie Lauren | Off. Anne Schanne
(as Julie Grossberg) |
| Larry Hull | Charles Flavin
(as Larry E. Hull) |
| Mary West Miller | Lydia Benson |
| Richard Pelzman | Newton Stuart |
| Ralph Tabakin | Dr. Scheiner, M.E. |
| Sharon Ziman | Naomi |
| Clayton LeBouef | Capt. George Barnfather
(uncredited) |