| Anna Torv | Alternate Olivia Dunham |
| Joshua Jackson | Peter Bishop
(credit only) |
| Lance Reddick | Phillip Broyles
(credit only) |
| Blair Brown | Nina Sharp
(credit only) |
| Jasika Nicole | Alternate Astrid Farnsworth |
| John Noble | Dr. Walter Bishop /
Walternate |
| Alon Aboutboul | Dr. Armand Silva |
| Seth Gabel | Alternate Lincoln Lee |
| Philip Winchester | Frank Stanton |
| Julie McNiven | Mona Foster |
| Ryan McDonald | Alternate Brandon Fayette |
| Kirk Acevedo | Alternate Charlie Francis |
| Joan Chen | Reiko |
| Donovan Cerminara | EMT |
| Tristan Jensen | ND Agent #1 |
| Eric Keenleyside | Jerry Bissell |
| Lea Kovach | Movie Star |
| Siobhan McCarthy | Waitress |
| David Milchard | Harry Millman |
| Roz Murray | Neuro Psychologist |
| Chris Shields | ND Agent #3 |
| Haig Sutherland | Ned Dolan |
| Jarrod Terrell | Danny |
| John Treleaven | Lone Traveler |