| Jennifer Aniston | Rachel Green |
| Courteney Cox | Monica Geller-Bing
(as Courteney Cox Arquette) |
| Lisa Kudrow | Phoebe Buffay |
| Matt LeBlanc | Joey Tribbiani
(as Matt Le Blanc) |
| Matthew Perry | Chandler Bing |
| David Schwimmer | Dr. Ross Geller |
| Paul Rudd | Mike Hannigan |
| Dedee Pfeiffer | Mary Ellen Jenkins |
| Elaine Hendrix | Sally |
| Gregory White | Dr. Gettleman |
| Angee Hughes | The Nurse |
| Greta Sesheta | The Receptionist |
| Ashly Holloway | The Girl in the Doctor's Office |
| Logan Hudson | The Boy in the Doctor's Office |
| Elizabeth Davidson | Emma Geller-Green
(uncredited) |
| Kim Harris | Woman in Coffee House
(uncredited) |
| Jodi Knotts | Dr. Toes
(uncredited) |
| James Michael Tyler | Gunther
(uncredited) |