| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Taylor Kitsch | Tim Riggins |
| Jesse Plemons | Landry Clarke |
| Aimee Teegarden | Julie Taylor |
| Michael B. Jordan | Vince Howard |
| Jurnee Smollett | Jess Merriweather |
| Matt Lauria | Luke Cafferty |
| Brad Leland | Buddy Garrity |
| Dana Wheeler-Nicholson | Angela Collette |
| Lorraine Toussaint | Bird Merriweather |
| D.W. Moffett | Joe McCoy |
| Jeremy Sumpter | J.D. McCoy |
| Dora Madison | Becky Sproles
(as Madison Burge) |
| Derek Phillips | Billy Riggins |
| Stacey Oristano | Mindy Riggins |
| Russell DeGrazier | Coach Stan Traub |
| Drew Waters | Wade Aikmen |
| Blue Deckert | Mac McGill |
| Timothy F. Crowley | Coach Crowley |
| Cedric Neal | Kennard Royce |
| Troy Anthony Hogan | Principal Burnwell
(as Troy Hogan) |
| David Born | Superintendent Dunley |
| Lamarcus Tinker | Dallas Tinker |
| Aaron Spivey-Sorrells | Coach Spivey
(as Aaron L. Spivey-Sorrells) |
| Kevin Saunders | Lester Daniels |
| Danny James Hunter | Deacon Floyd Malone |
| Lawrence Varnado | Mo Hall |
| Joshua D. Moody | Moody |
| Emerico McClinton | Police Officer #1 |
| Devin Jacobson | Police Officer #2 |
| Cynthia Jackson | Rita Brown |
| Chris Freihofer | Jake Reisen |
| Ausar Moore | Befuddled Lion |
| Michael Crabtree | Sheriff |
| Todd Terry | William Simmons |
| Amparo García | Midwife
(as Amparo Garcia Crow) |
| Charlene Gorman | Hospital Administrator |
| David Cowgill | Slammin' Sammy |
| Tony Bottorff | Dillon Coach Tony
(uncredited) |
| Tom Lopez | Protester
(uncredited) |
| John Christian Love | Lions Player
(uncredited) |
| Desiree McKinney | Chante
(uncredited) |
| Jamie Preyer | Nurse
(uncredited) |
| Nic Quardero | Lions Player
(uncredited) |
| Christopher J Rusho | Protester
(uncredited) |