| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Taylor Kitsch | Tim Riggins |
| Jesse Plemons | Landry Clarke
(credit only) |
| Aimee Teegarden | Julie Taylor |
| Michael B. Jordan | Vince Howard |
| Jurnee Smollett | Jess Merriweather |
| Matt Lauria | Luke Cafferty |
| Steve Harris | Virgil Merriweather |
| Alicia Witt | Cheryl |
| Matt Barr | Ryan Lowry |
| Barry Tubb | Tom Cafferty |
| Dora Madison | Becky Sproles
(as Madison Burge) |
| Derek Phillips | Billy Riggins |
| Russell DeGrazier | Coach Stan Traub |
| Angela Rawna | Regina Howard |
| Kathleen Griffith | Margaret Cafferty |
| Cedric Neal | Kennard Royce |
| Timothy F. Crowley | Coach Crowley |
| Lawrence Varnado | Mo Hall |
| Danny James Hunter | Deacon Floyd Malone |
| Peter Harrell Jr. | Damon Gaston |
| Isaac Smith | Caleb Merriweather |
| Tom Green | Reverend |
| Steven Dziobak | Linebacker |
| Leng Wong | Hospital Administrator |
| Sonny Castillo | Dude
(as Louis Sonny Castillo) |
| Scott Kimbrough | Other Dude |
| Rachel Watson | Bartender |
| Amber Dupuy | Administrative Nurse |
| Michael D. Conway | Doctor Vogel
(as Michael Conway) |
| Dale Watson | Junkyard Owner |
| Rob McGrath | Church Goer |
| Edward Morgan | Rehab Counselor |
| Ernest James | Calvin Brown
(uncredited) |
| Stacey Oristano | Mindy Collette
(uncredited) |
| Lamarcus Tinker | Dallas Tinker
(uncredited) |