| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street
(credit only) |
| Aimee Teegarden | Julie Taylor |
| Jessalyn Gilsig | Shelley Hayes |
| Brad Leland | Buddy Garrity |
| Daniella Alonso | Carlotta Alonso |
| Ben Ciaramello | Santiago Herrera
(as Benny Ciaramello) |
| Jana Kramer | Noelle Davenport |
| Taylor Nichols | Kevin |
| Merrilee McCommas | Pam Garrity |
| Joey Truty | Little Buddy Garrity |
| Kate Krause | Tabby Garrity |
| Megan Moser | Lois |
| Blue Deckert | Mac McGill |
| James Powers | Bradley |
| Brian Thornton | Coach Daniel Dickens |
| Trevor Doyle Nelson | Riley
(as Trevor Nelson) |
| Daniel Crouch | Chip Gizzi-Rozzi |
| Cory Hall | Eddie Gizzi-Rozzi |
| Cody Hall | Albert Gizzi-Rozzi |
| Kendrick Jefferson | Kendrick |
| Victor Diaz | Channel 5 Reporter |
| Jim Spencer | TV Weatherperson |
| Raquel Fitzgerald | Food Fight Girl |
| Ronald G. Prellop | Store Manager |
| Paul Fischer | Movie Husband |
| Kimberly Bramlett | Movie Wife |
| Aaron Bishop | Lonely Man at the Bar
(uncredited) |
| Chris Blake | Dillon Student
(uncredited) |
| D.J. Castillo | Library Student
(uncredited) |
| Randy Coy | Panther Booster
(uncredited) |
| Mardi DeLong | Student at Dance
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Travis Owens | 2008-2008
(uncredited) |
| Jaime De La Rosa | Tyra's Diner Customer
(uncredited) |
| Lincoln Rose | TV Reporter #2
(uncredited) |
| Gary Teague | Teacher
(uncredited) |
| Rett Terrell | Dillon Student
(uncredited) |