| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Glenn Morshower | Chad Clarke |
| Jessalyn Gilsig | Shelley Hayes |
| Brad Leland | Buddy Garrity |
| Ben Ciaramello | Santiago Herrera
(as Benny Ciaramello) |
| Daniella Alonso | Carlotta Alonso |
| Kevin Rankin | Herc |
| Liz Mikel | Corrina Williams |
| Whitney McCauley | Sheila Williams |
| Louanne Stephens | Grandma Saracen |
| Blue Deckert | Coach Mac McGill |
| Libby Villari | Mayor Rodell |
| Katherine Willis | Mrs. Joanne Street |
| Mark Nutter | Mr. Mitchell Street |
| Joey Oglesby | Guy Raston |
| Pat Hazell | Detective Tambor |
| Timothy F. Crowley | Coach Crowley
(as Tim Crowley) |
| Peter Heckman | Pastor |
| Tamara Jolaine | Erin
(as Tamara Haasan) |
| Thomas E. Davis | Dude #1 |
| Kathleen Hays | Isabella
(as Kathleen Hamm) |
| Brady Coleman | Lawyer |
| David Cowgill | Slammin' Sammy |
| Aaron Garza | Panthers Defensive Captian |
| Brian Gamble | S.P. Offensive Lineman |
| D.J. Morrison | Service Manager |
| Wendy Garett | Announcer |
| Gene Cervenka | Restaurant Patron
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Madilyn Landry | Gracie Belle Taylor
(uncredited) |
| Stacey Oristano | Mindy Collette
(uncredited) |
| Ray L. Perez | Deputy
(uncredited) |
| Rebecca Richardson Phillips | Coach Macgill's Wife
(uncredited) |
| Will Scoville | Assistant Coach
(uncredited) |
| Gary Teague | Church Member
(uncredited) |
| Shain E. Thomas | Restaurant Patron
(uncredited) |
| Steven Walters | Glenn Reed
(uncredited) |
| Heath Young | Football fan
(uncredited) |