| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Glenn Morshower | Chad Clarke |
| Jessalyn Gilsig | Shelley Hayes |
| Brad Leland | Buddy Garrity |
| Ben Ciaramello | Santiago Herrera
(as Benny Ciaramello) |
| Alanna Ubach | Roberta 'Bobbie' Roberts |
| Kim Smith | Lauren Davis |
| Derek Phillips | Billy Riggins |
| Blue Deckert | Mac McGill |
| Liz Mikel | Corrina Williams |
| Nieko Mann | Noannie Williams |
| Whitney McCauley | Sheila Williams |
| Timothy F. Crowley | Coach Crowley
(as Tim Crowley) |
| Steven Walters | Glenn Reed |
| James Powers | Bradley |
| Aaron Spivey-Sorrells | Assistant Coach |
| Mark Nutter | Mr. Mitchell Street |
| Katherine Willis | Mrs. Joanne Street |
| Peter Malof | Principal Brecker |
| James Phillips | Rev. Phillips |
| Steve Shearer | Detective Blair |
| Pat Hazell | Detective Tambor |
| Billy Jaeger | Jimmy |
| Erick Smart | Shrader |
| Chad Brannon | Lucas Mize
(uncredited) |
| Parker Danks | Student at Locker
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Pablo Flores | Coach Pablo
(uncredited) |
| Jana Kramer | Noelle Davenport
(uncredited) |