| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Chris Mulkey | Coach Bill McGregor |
| Glenn Morshower | Chad Clarke |
| Brad Leland | Buddy Garrity |
| Daniella Alonso | Carlotta Alonso |
| Kevin Rankin | Herc |
| Brooke Langton | Jackie Miller |
| Derek Phillips | Billy Riggins |
| Louanne Stephens | Grandma Saracen |
| Alejandro Rose-Garcia | The Swede |
| Blue Deckert | Coach Mac McGill |
| Steven Walters | Glenn Reed |
| Wilbur Fitzgerald | TMU Coach Boyd |
| Libby Villari | Mayor Rodell |
| Liz Mikel | Corrina Williams |
| Whitney McCauley | Sheila Williams |
| Nieko Mann | Noannie Williams |
| Dylan Williams | Jimmy |
| Ryan Ciardo | Panther #1 |
| James Kenneth Phillips | Preacher |
| Williams G. Ross | Reporter |
| Karen Elvonna | Waitress |
| James Powers | Bradley |
| Carol Farabee | Mary Clarke |
| Preston Grice | Assistant Coach |
| Deke Anderson | ER Doctor |
| Jamison Driskill | Jackson |
| Chris Osborn | Hudson |
| Jennifer Blair | Becka |
| Kate Krause | Tabby Garrity |
| Joey Truty | Little Buddy Jr. |
| Timothy F. Crowley | Coach Crowley |
| Ericka Henderson | Alamo Freeze Girl |
| David Cowgill | Slammin' Sammy |
| Gene Cervenka | Sideline Reporter
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Pablo Flores | Coach Pablo
(uncredited) |
| David Lyman | Booster
(uncredited) |
| Bill Ross | Reporter
(uncredited) |
| Joshua Ryan | Greer - Football Player #12
(uncredited) |
| Gary Teague | Church Member
(uncredited) |
| Carol Vincent | Football Fan
(uncredited) |