| Connie Britton | Tami Taylor |
| Kyle Chandler | Eric Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Chris Mulkey | Coach Bill McGregor |
| Brad Leland | Buddy Garrity |
| Glenn Morshower | Chad Clarke |
| Taylor Nichols | Pamela's Boyfriend |
| Derek Phillips | Billy Riggins |
| Merrilee McCommas | Pam Garrity |
| Louanne Stephens | Grandma Saracen |
| Liz Mikel | Corrina Williams |
| Alejandro Rose-Garcia | The Swede |
| Matt McTighe | Mike the Rapist |
| Libby Villari | Mayor Rodell |
| Blue Deckert | Mac McGill |
| Joey Truty | Little Buddy Jr. |
| Kate Krause | Tabby Garrity |
| Megan Moser | Lois |
| James Kenneth Phillips | Reverend Phillips |
| Amanda Phillips | Meg (Swede's Girl) |
| Amparo García | Female Doctor |
| Cindy Thomas | Delivery Nurse |
| James Powers | Bradley |
| Katherine Willis | Mrs. Street |
| Mark Nutter | Mr. Street |
| Erika Waldorf | The Swede's Fan
(as Erika Adams Waldorf) |
| Timothy F. Crowley | Coach Crowley |
| David Cowgill | Slammin' Sammy |
| Cody Esquivel | Churchgoer
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Pablo Flores | Coach Pablo
(uncredited) |
| Diane Howard | Swimmer
(uncredited) |
| Brooke Langton | Jackie Miller
(uncredited) |
| David Lyman | Booster
(uncredited) |
| Stacey Oristano | Mindy Collette
(uncredited) |
| David Sturgeon | Churchgoer
(uncredited) |
| Gary Teague | Teacher
(uncredited) |
| Carol Vincent | Churchgoer
(uncredited) |