| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Dana Wheeler-Nicholson | Angela Collette |
| Brooke Langton | Jackie Miller |
| Aldis Hodge | Ray 'Voodoo' Tatum |
| Brad Leland | Buddy Garrity |
| Jae Head | Bo Miller |
| Blue Deckert | Mac McGill |
| Louanne Stephens | Mrs. Saracen |
| Derek Phillips | Billy Riggins |
| Stacey Oristano | Mindy Collette |
| David Cowgill | Slammin' Sammy |
| Merrilee McCommas | Pam Garrity |
| Kate Krause | Tabby Garrity |
| Liz Mikel | Corrina Williams |
| Nieko Mann | Noannie Williams |
| Whitney McCauley | Sheila Williams |
| Libby Villari | Mayor Rodell |
| Katherine Willis | Joanne Street |
| Mark Nutter | Mitchell Street |
| D'Anthony Palms | Anton |
| Aundrus Poole | Seale |
| James Powers | Bradley Cole |
| Kendrick Jefferson | Baxter |
| Timothy F. Crowley | Coach Crowley |
| Aaron Spivey-Sorrells | Coach Spivey |
| Lisa Rhoden | Reporter |
| Steve Muccini | Team Doctor |
| Dana Austin | Elderly Nurse |
| Tom Costello Jr. | Mustang Coach
(as Tom Costello) |
| Bryan Aguinaga | Football Player
(uncredited) |
| Davy Aguirre | Panther Booster
(uncredited) |
| Geoffrey Betts | TV Camera Operator
(uncredited) |
| Angela Burns | Rally Girl
(uncredited) |
| D.J. Castillo | Athletic Trainer
(uncredited) |
| Gene Cervenka | Panther Football Fan
(uncredited) |
| Randy Coy | Panther Booster
(uncredited) |
| Richard Dodwell | Football Fan
(uncredited) |
| Osa Eke | Football Player
(uncredited) |
| Morgan English | Football Fan
(uncredited) |
| Bob Fanucchi | Booster Dad
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Pablo Flores | Coach Pablo
(uncredited) |
| Spencer Greenwood | Football Team Manager
(uncredited) |
| Jason T. Henderson | Ex-Player
(uncredited) |
| Pattie James | Reporter
(uncredited) |
| Catherine Lawrence Kinslow | Pep Rally /
Parade Fan
(uncredited) |
| Mark T. Lee | Boom Operator
(uncredited) |
| Heath McGough | Booster Dad
(uncredited) |
| Toby Metcalf | Booster
(uncredited) |
| Scott Mueller | Football Player
(uncredited) |
| Brian Nicholas | Security Guard
(uncredited) |
| Donna Sue Nickason | Panther Booster
(uncredited) |
| Starla Osburn | Stadium Fan
(uncredited) |
| Wil Pollard | Football Player
(uncredited) |
| Chris Prock | Football Player
(uncredited) |
| Kathryn Rawson | Cheerleader
(uncredited) |
| Rhonda Reeves | Panther Banquet Booster
(uncredited) |
| Eric Rhoades | Press Sound Recordist
(uncredited) |
| Kim Rickards | Fan
(uncredited) |
| Laura Veloz Ritter | Booster Parent
(uncredited) |
| Isaac Rodriguez | Reporter /
Diner Customer
(uncredited) |
| Michael J. Rowbottom | Football Banquet Booster
(uncredited) |
| Joshua Ryan | Greer - Football Player #12
(uncredited) |
| Craig Simons | Security Guard
(uncredited) |
| Jeremy Summers | Fan
(uncredited) |
| Gary Teague | Teacher
(uncredited) |
| Joey Truty | Little Buddy Garrity
(uncredited) |
| Jennifer Roxanne Vasquez | Radio Reporter
(uncredited) |
| Heath Young | Football fan
(uncredited) |