| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Brooke Langton | Jackie Miller |
| Aasha Davis | Waverly Grady |
| Alexandra Holden | Suzy |
| Aldis Hodge | Ray 'Voodoo' Tatum |
| Brad Leland | Buddy Garrity |
| Jae Head | Bo Miller |
| Blue Deckert | Mac McGill |
| Louanne Stephens | Mrs. Saracen |
| Libby Villari | Mayor Rodell |
| Merrilee McCommas | Pam Garrity |
| Kate Krause | Tabby Garrity |
| Joey Truty | Little Buddy Garrity |
| Ryan Ciardo | Chuck Pierce |
| Aundrus Poole | Reggie Seale |
| James Powers | Bradley Cole |
| Terrenee Knight | Rosario |
| Aaron Spivey-Sorrells | Coach Spivey |
| Timothy F. Crowley | Coach Crowley
(as Timothy Crowley) |
| Mark Gil | Detective Kirk Dunver |
| Will Parsons | Non-Panther Student |
| William Bradley Wright | Terrence Boyd |
| Pattie James | Reporter
(as Pattie Hart) |
| Bryan Aguinaga | Football Player
(uncredited) |
| Dan Eggleston | Booster
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Pablo Flores | Coach Pablo
(uncredited) |
| Scott Mueller | Football Player
(uncredited) |
| D'Anthony Palms | Anton
(uncredited) |
| Kathryn Rawson | Cheerleader
(uncredited) |
| Joshua Ryan | Greer - Football Player #12
(uncredited) |
| Gary Teague | Teacher
(uncredited) |