| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Brett Cullen | Walt Riggins
(credit only) |
| Kevin Rankin | Herc |
| Aasha Davis | Waverly Grady |
| Brad Leland | Buddy Garrity |
| Blue Deckert | Mac McGill |
| Liz Mikel | Corrina |
| Stacey Oristano | Mindy Collette |
| David Cowgill | Slammin' Sammy |
| Timothy F. Crowley | Coach Crowley
(as Timothy Crowley) |
| Michael Waxman | TABC Agent |
| D'Anthony Palms | Anton |
| Aundrus Poole | Reggie Seale |
| Thaxon Hill | Hayskins |
| Drew Cauthorn | McGinn |
| Brendan Flores | Burdette |
| Derek Chase Hickey | Allspaugh |
| Bryan Chafin | Stager |
| Ken Thomas | Jail Officer |
| Kiri Weatherby | Female Student |
| Deanna Brochin | Backroom Stripper |
| Amon Lewis | Cardinal Player #1 |
| Jonas Crafts | Cardinal Player #2 |
| Chip Mayfield | Brant Coach |
| John Arkinson | Referee |
| Tom Procida | UIL Jack Unger |
| Brent Werzner | Brant Officer #1 |
| Gregor Haley | Brant Officer #2
(as Greg Hall) |
| Linda Brister | Jewelry Store Owner |
| Joe Azzato | Cardinal Fan
(uncredited) |
| Angela Burns | Rally Girl
(uncredited) |
| Kimberly Ensey | Pretty Girl on 6th Street
(uncredited) |
| Archie Fields | Panther Football Player
(uncredited) |
| Pablo Flores | Coach Pablo
(uncredited) |
| Alexandra Holden | Suzy
(uncredited) |
| Daniel B. Howard | Football Player
(uncredited) |
| Wil Pollard | Football Player
(uncredited) |
| Joshua Ryan | Greer - Football Player #12
(uncredited) |
| Will Scoville | Dillon Police Officer
(uncredited) |
| Scott A. Stevens | Coach, Opposing Team
(uncredited) |
| Gary Teague | Dillon Panther Football Fan
(uncredited) |
| William Throckmorton | Reporter
(uncredited) |
| Angela Ware | Pool Hall Patron
(uncredited) |
| Barney Welch | Counselor Barney
(uncredited) |
| Heath Young | Football fan
(uncredited) |