| Kyle Chandler | Eric Taylor |
| Connie Britton | Tami Taylor |
| Gaius Charles | Brian 'Smash' Williams |
| Zach Gilford | Matt Saracen |
| Minka Kelly | Lyla Garrity |
| Taylor Kitsch | Tim Riggins |
| Adrianne Palicki | Tyra Collette |
| Jesse Plemons | Landry Clarke |
| Scott Porter | Jason Street |
| Aimee Teegarden | Julie Taylor |
| Kevin Rankin | Herc |
| Brad Leland | Buddy Garrity |
| Blue Deckert | Mac McGill |
| Derek Phillips | Billy Riggins |
| Chad Brannon | Lucas Mize |
| Libby Villari | Mayor Rodell |
| Richard Dillard | Grady Hunt |
| Katherine Willis | Joanne Street |
| Mark Nutter | Mitchell Street |
| Liz Mikel | Corrina |
| Nieko Mann | Noannie
(as Brittany 'Nieko' Mann) |
| Whitney McCauley | Sheila |
| Stacey Oristano | Mindy Collette |
| Robert O. Boothby | Corey
(as Robert Boothby) |
| Damon Carney | Coach Quinsberry |
| Loomis Warren | Linebacker Owen Price |
| Dante Ponzanelli | Football Player |
| Bryan Aguinaga | Football Player
(uncredited) |
| Ravin Alexander | Christina
(uncredited) |
| Michelle Brew | Rally Girl
(uncredited) |
| Angela Burns | Rally Girl
(uncredited) |
| D.J. Castillo | Athletic Trainer
(uncredited) |
| Erik Collins | Spectator
(uncredited) |
| Matt Connely | Last Year's Player
(uncredited) |
| Mardi DeLong | Raver
(uncredited) |
| Kelley Estes | Rally Girl
(uncredited) |
| Regina Gordon | Water Girl
(uncredited) |
| Max Johnston | Homecoming Band
(uncredited) |
| Kate Krause | Tabby Garrity
(uncredited) |
| Keith Langford | Homecoming Band
(uncredited) |
| David Maldonado | Security Guard
(uncredited) |
| Peter Malof | Principal Brecker
(uncredited) |
| Robert E. Martinez | Alumni
(uncredited) |
| Brent McGregor | Kastor
(uncredited) |
| Melinda Mendoza | Bartender
(uncredited) |
| Lowell Moore | (uncredited) |
| Rupert-Anthony Ortiz | Panther Football Player #70
(uncredited) |
| Amy Quick Parrish | Neighbor with Car
(uncredited) |
| Isaac Rodriguez | Reporter /
Diner Customer
(uncredited) |
| Kevin Russell | Homecoming Band
(uncredited) |
| Joshua Ryan | Greer - Football Player #12
(uncredited) |
| Jimmy Smith | Homecoming Band
(uncredited) |
| Gary Teague | Dillon Panther Alumni
(uncredited) |
| Justin Lee Tidwell | Former Homecoming King
(uncredited) |
| Rolando J. Vargas | College Jock
(uncredited) |
| Heath Young | Football fan
(uncredited) |