| Zendaya | Rue Bennett |
| Maude Apatow | Lexi Howard |
| Angus Cloud | Fezco |
| Eric Dane | Cal Jacobs |
| Alexa Demie | Maddy Perez |
| Jacob Elordi | Nate Jacobs |
| Barbie Ferreira | Kat Hernandez |
| Nika King | Leslie Bennett |
| Storm Reid | Gia Bennett |
| Hunter Schafer | Jules Vaughn |
| Algee Smith | Chris McKay |
| Sydney Sweeney | Cassie Howard |
| Alanna Ubach | Suze |
| Austin Abrams | Ethan |
| Elpidia Carrillo | Sonia |
| Paula Marshall | Marsha |
| Tyler Chase | Custer |
| John Ales | David |
| Mercedes Colon | Kat's Mom |
| Allie Marie Evans | Natalie |
| Meeko | Mouse |
| Janice LeAnn Brown | 6-Year-Old Rue |
| Brynda Mattox | Fezco's Grandmother |
| Bruce Wexler | Robert |
| Caleb Coffee | Young Kid |
| Evans Forde | Wealthy Man |
| Anthony S. Johnson | Doctor |
| Chuck McCollum | Surgeon |
| Evan Michael Pinsonnault | Football Announcer |
| Mel Fair | Football Announcer |
| Jarrett Austin Brown | Friend |
| Roy Lee Jones | Man in Waiting Room |
| Rebecca Lee | Hospital Nurse |
| Stephanie 'Stevvi' Alexander | Nurse |
| Kamilah Barrett | Station Employee |
| Ryan Bertroche | Random Hot Guy |
| Keva Walker | Dancer |
| Javon 'Wanna' Walton | Ashtray |
| Paige Annette | Female |
| Mariela Arteaga | Dancer |
| Tara Brook | Dancer |
| Roman Carter | Dirty Dancer |
| Danny Dolan | Dancer |
| Michelle Foster | Dancer |
| Noah Harrison | Large Defensive Tackle |
| Raquel Horsford | Dancer |
| Leroy Lubin | Trumpet Player |
| Liv Mai | Dancer |
| Chris Moss | Dancer |
| Maria Katre Osler | Band Member |
| Vitta Quinn | Dancer |
| Edward Redmond | Head Football Coach |
| Jivanta Roberts | Dancer |
| Michael Sasaki | Ice Skating Coach |
| Julie Schmid | Dancer |
| Alyson Van | Dancer |