| Kevin Connolly | Eric Murphy |
| Adrian Grenier | Vincent Chase |
| Kevin Dillon | Johnny 'Drama' Chase |
| Jerry Ferrara | Turtle |
| Perrey Reeves | Mrs. Ari |
| Rex Lee | Lloyd Lee |
| Jeremy Piven | Ari Gold |
| Gary Cole | Andrew Klein |
| Emmanuelle Chriqui | Sloan |
| Alexis Dziena | Ashley |
| Jami Gertz | Marlo Klein |
| Autumn Reeser | Lizzie Grant |
| Kate Mara | Brittany |
| Beverly D'Angelo | Barbara Miller |
| Aaron Sorkin | Aaron Sorkin |
| Peter Stormare | Aaron Cohen |
| Laura Levy | Miller Gold Girl |
| Tammy Lacock | Andrew's Assistant |
| Jonathan Avigdori | Israeli Security Guard #1 |
| Adam Karst | Israeli Security Guard #2 |
| Antal Kalik | Big Yoni |
| Michael Hilow | Little Yoni |
| John Eleton | Murphy Agent |
| Kevin Lapsley | Wait Staff |
| David J Law | Miller Gold Agent |
| Turk Matthews | Office Heckler |
| Jessica Radloff | (uncredited) |
| Marisa Saks | Sloan's party coordinator |