| Anthony Edwards | Mark Greene |
| George Clooney | Doug Ross |
| Sherry Stringfield | Susan Lewis |
| Noah Wyle | John Carter |
| Julianna Margulies | Carol Hathaway |
| Gloria Reuben | Jeanie Boulet |
| Eriq La Salle | Peter Benton |
| Abraham Benrubi | Jerry Markovic |
| Robert Cicchini | Channel 5 Chopper Reporter |
| Erik von Detten | Ben Larkin |
| Luis Avalos | Private-Practice Pediatrician |
| Christine Elise | Harper Tracy |
| Andrea Parker | Linda Farrell |
| William H. Macy | Dr. David Morgenstern |
| Ellen Albertini Dow | Mrs. Riblet |
| Cynthia Mace | |
| Chase Masterson | Mrs. Phillips |
| J. Madison Wright | Molly Phillips |
| Peter Gregory | Mr. Phillips |
| Conni Marie Brazelton | Nurse Connie Oligario |
| Deezer D | Nurse Malik McGrath |
| Lily Mariye | Nurse Lily Jarvik |
| Vanessa Marquez | Nurse Wendy Goldman |
| Zach Charles | Joey Larkin |
| Yolanda Gaskins | TV News Reporter Dr. Beth Mahoney |
| Will Jeffries | Mr. Larkin |
| Nika Kolodziej | Amber |
| Kurt Naebig | Paramedic |
| Richard Pickren | Jimmy, TV Helicopter Pilot |
| Montae Russell | Dwight Zadro |
| Warner Saunders | News Anchor |
| Stephanie Sawyer | Mindy |
| Raymond D. Turner | Security Guard |
| Jim Childs | Patient |
| Justin Frazier | Paramedic |