| Jonathan Rhys Meyers | King Henry VIII |
| Henry Cavill | Charles Brandon |
| James Frain | Thomas Cromwell |
| Alan Van Sprang | Sir Francis Bryan |
| Max von Sydow | Cardinal Von Waldburg |
| Sarah Bolger | Mary Tudor |
| David Bradley | Will (Court Fool) |
| Max Brown | Edward Seymour |
| Charlotte Salt | Lady Ursula Misseldon |
| Mark Hildreth | Cardinal Reginald Pole |
| Simon Ward | Bishop Gardiner |
| Anthony Brophy | Ambassador Bishop Chapuys |
| Rod Hallett | Richard Rich |
| Seamus Moran | Packington |
| Karl Shiels | Packington's Killer |
| Frank McCusker | Risley |
| Jane Brennan | Lady Margaret Bryan |
| Julian Bastida | Imperial Officer Caserta |
| Andrew McNair | Thomas Seymour |
| Jack Lynch | Pole's Servant |
| Rebekah Wainwright | Catherine Brandon |
| Martin Casey | Yellow Retainer |
| Jonathan Gallagher | Gawen |
| Ian Beattie | Sergeant at Arms |
| Simon Keogh | Official at Hampton Court |
| Ciaran O'Grady | Yeoman |
| Guy Carleton | Chamberlain |
| Liam Young | Lord Hassey |
| David Lennox | Earl of Oxford |
| Emma Hamilton | Anne Stanhope |
| Gordon Sterne | Bishop Tunstall |
| David Verne | Thomas le Roux |
| Annika Hammerton | Queen Jane's Lady-in-Waiting |