| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti
(credit only) |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Aida Turturro | Janice Soprano Baccalieri |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Frank Vincent | Phil Leotardo |
| John Ventimiglia | Artie Bucco |
| Dan Grimaldi | Patsy Parisi |
| Sharon Angela | Rosalie Aprile |
| Kathrine Narducci | Charmaine Bucco
(as Katherine Narducci) |
| Peter Bogdanovich | Dr. Elliot Kupferberg |
| Edoardo Ballerini | Corky Caporale |
| Matt Servitto | Agent Dwight Harris |
| Eric Mangini | Eric Mangini |
| Julie Mangini | Julie Mangini |
| Arthur J. Nascarella | Carlo Gervasi
(as Arthur Nascarella) |
| Greg Antonacci | Butch DeConcini
(as Gregory Antonacci) |
| Frank John Hughes | Walden Belfiore |
| John Cenatiempo | Anthony Maffei |
| Lenny Venito | James 'Murmur' Zancone |
| Joe Perrino | Jason Gervasi |
| Michael Drayer | Jason Parisi |
| John 'Cha Cha' Ciarcia | Albie Cianflone |
| Emily Wickersham | Rhiannon Flammer |
| Artie Pasquale | Burt Gervasi |
| Anthony J. Ribustello | Dante Greco |
| Dominic Chianese Jr. | Dominic |
| Rick Aiello | Ray-Ray D'Abaldo
(as Ricky Aiello) |
| Peter Bucossi | Petey B.
(as Pete Bucossi) |
| Carlo Giuliano | Italo |
| Davide Borella | Roberto
(as Davidé Borella) |
| Matilda Szydagis | Yaryna
(as Matilda Downey) |
| Aleks Shaklin | Yaryna's Father |
| Susan Aston | Evelyn |
| Merissa Morin | Isabel |
| Henry Glovinsky | Derek |
| Jeffrey M. Marchetti | Peter 'Bissell' LaRosa |
| Adam Heller | Arnold Bellows |
| Mimi Lieber | Stacey Bellows |
| Connie Teng | Yaolin |
| Peter Benedek | Ken |
| Shannon Koob | Joyce |
| John Mainieri | Ira Shortz |
| Jeff Talbott | Father |
| Ian Colletti | Kid |
| Lauren Potter | Dancer |
| Angelo Massagli | Bobby Baccalieri Jr. |
| Miryam Coppersmith | Sophia Baccalieri |
| Avery Elaine Pulcher | Domenica Baccalieri |
| Emily Ruth Pulcher | Domenica Baccalieri |
| Alexander Blaise | French chef
(uncredited) |
| Michael DeArmey | Body Guard
(uncredited) (unconfirmed) |
| Jennifer Hall | Girl in Hospital with AJ
(uncredited) |
| Jalil Jay Lynch | Incident Biker
(uncredited) |
| Joe Mancini | Bada Bing Crew
(uncredited) |
| Michael Masucci | Bar patron
(uncredited) |
| Bob Pepper | Craps Player
(uncredited) |
| Erik Ramos | Desk Clerk
(uncredited) |