| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Aida Turturro | Janice Soprano Baccalieri |
| Steve Schirripa | Bobby 'Bacala' Baccalieri |
| Frank Vincent | Phil Leotardo |
| John Ventimiglia | Artie Bucco |
| Ray Abruzzo | Carmine Lupertazzi Jr. |
| Joseph R. Gannascoli | Vito Spatafore |
| Dan Grimaldi | Patsy Parisi |
| Steve Buscemi | Man |
| Tim Daly | J.T. Dolan |
| Ron Leibman | Dr. Lior Plepler |
| Henry O | Monk #1 |
| Sharon Angela | Rosalie Aprile |
| Carl Capotorto | Little Paulie Germani |
| Tony Darrow | Larry Boy Barese |
| Max Casella | Benny Fazio |
| Lenny Venito | James 'Murmur' Zancone |
| Ho Chow | Monk #2 |
| Simon Sinn | Monk #3 |
| Bill Kurtis | Bill Kurtis |
| Elizabeth Bracco | Marie Spatafore |
| Maureen Van Zandt | Gabriella Dante |
| Tom Aldredge | Hugh DeAngelis |
| Suzanne Shepherd | Mary DeAngelis |
| Paul Schulze | Father Phil Intintola |
| Geraldine LiBrandi | Patty Leotardo |
| Will Janowitz | Finn Detrolio |
| Ed Vassallo | Tom Giglione |
| Danielle Di Vecchio | Barbara Giglione |
| James Vincent Romano | Cary Di Bartolo |
| William DeMeo | Jason Molinaro |
| Traci Kindell | Nurse Leontine Overall |
| Luis Ruiz | Superintendent |
| David Francis Calderazzo | Nick 'Spags' Spagnelli |
| Luz Lor | Nurse Aquino |
| Anjali Bhimani | Dr. Budraja |
| Carmen López | Nurse Alfeo |
| Edward Watts | Bartender |
| Mueen Jahan | Dr. Vahabsideh |
| Joe Delafield | Intern |
| C.S. Lee | Dr. Ba |
| Matthew Stocke | EMT |
| Angel Fajardo | Colombian #1 |
| Chris Colombo | Colombian #2 |
| David Benaroya | Fat Jew |
| Loukas Papas | Carlos The Maitre D |
| Paula Rittie | AA member |
| Morgan Saylor | Young Meadow |
| Dared Wright | Hospital Worker |