| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Drea de Matteo | Adriana La Cerva |
| Aida Turturro | Janice Soprano |
| Federico Castelluccio | Furio Giunta |
| Vincent Curatola | Johnny 'Sack' Sacramoni |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Joe Pantoliano | Ralph Cifaretto |
| Peter Riegert | Assemblyman Zellman |
| Vondie Curtis-Hall | Maurice Tiffen
(as Vondie Curtis Hall) |
| Matthew Del Negro | Brian Cammarata |
| Oksana Lada | Irina Peltsin |
| Carl Capotorto | Little Paulie Germani |
| Robert Funaro | Eugene Pontecorvo |
| Lola Glaudini | Agent Deborah Ciccerone |
| Karen Young | Agent Robyn Sanseverino |
| Frank Pellegrino | Bureau Chief Cubitoso |
| Sharon Angela | Rosalie Aprile |
| Maureen Van Zandt | Gabriella Dante |
| Vanessa Liguori | Terri |
| Matt Servitto | Agent Dwight Harris |
| Joseph R. Gannascoli | Vito Spatafore |
| Lewis J. Stadlen | Dr. Ira Freid |
| Richard Ziman | Stan Gurman |
| Dan Grimaldi | Patsy Parisi |
| Richard Maldone | Albert Barese |
| Max Casella | Benny Fazio |
| Frank Santorelli | Georgie |
| Malcolm Barrett | Angelo Davis |
| Anna Mancini | Donna Parisi |
| Marianne Leone | Joanne Moltisanti |
| Patty McCormack | Liz La Cerva
(as Patty McCormick) |
| Messeret Stroman | Mecomia Williams |
| Melissa Maxwell | Regina Hicks |
| Sally Stewart | Lenore |
| Geany Masai | Loretta |
| Nichelle Hines | Felicia |
| Ephraim Benton | Saladin |
| Shawn Leggett | Keryl |
| Philliph Oden | Jemilo |
| Chad Tucker | Darryl |
| Matthew Weathers | Anklave |
| Jay Alvarez | Loan Officer |
| Victor Matamoros | Attorney |
| Bonnie Rose | Salesperson |
| Roy Milton Davis | Wino |
| Ali Wright | Kid |
| Angela Frye | Crackhead
(uncredited) |
| Gaetano LoGiudice | Bada Bing Patron
(uncredited) |
| Bobbie Phillips | Julie Costello
(archive footage) (uncredited) |
| Lauren Toub | Liz Diliberto
(uncredited) |