| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Drea de Matteo | Adriana La Cerva |
| Federico Castelluccio | Furio Giunta |
| Steve Schirripa | Bobby 'Bacala' Baccalieri |
| Sam McMurray | Dr. John Kennedy |
| Frank Wood | Dean Ross |
| Sully Boyar | Dr. Krakower |
| Dan Grimaldi | Patsy Parisi |
| Toni Kalem | Angie Bonpensiero |
| Tom Aldredge | Hugh DeAngelis |
| Suzanne Shepherd | Mary DeAngelis |
| Frank Santorelli | Georgie |
| Ilene S. Landress | Dr. Laurens |
| Ismail Bashey | Dr. Mehta |
| Peter Davies | Paxton |
| John Fiske | FBI Man |
| John Freudiger | Chooch |
| Lorenzo Gregorio | Miles |
| Tony Hale | RN Collins |
| Zachary Knower | Dr. Enloe |
| James Shanklin | Anesthesiologist |
| Shireen Kadivar | Middle Eastern Woman at Hospital |
| Pete Macnamara | Restaurant Patron |
| Joe Rosario | Bouncer |