| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Drea de Matteo | Adriana La Cerva |
| Aida Turturro | Janice Soprano |
| John Ventimiglia | Artie Bucco |
| Federico Castelluccio | Furio Giunta |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Robert Funaro | Eugene Pontecorvo |
| Kathrine Narducci | Charmaine Bucco
(as Katherine Narducci) |
| Nancy Marchand | Livia Soprano
(credit only) |
| Joe Pantoliano | Ralph Cifaretto |
| Jerry Adler | Hesh Rabkin |
| Peter Riegert | Assemblyman Ronald Zellman |
| Tom Aldredge | Hugh DeAngelis |
| Suzanne Shepherd | Mary DeAngelis |
| Alla Kliouka | Svetlana Kirilenko |
| Vincent Curatola | Johnny 'Sack' Sacramoni |
| John Fiore | Gigi Cestone |
| Joseph R. Gannascoli | Vito Spatafore |
| Dan Grimaldi | Patsy Parisi |
| George Loros | Raymond Curto |
| Richard Maldone | Albert Barese |
| Vincent Pastore | Salvatore 'Big Pussy' Bonpensiero |
| Gregory Alan Williams | Reverend James Jr.
(as Gregalan Williams) |
| Patrick Tully | Noah Tannenbaum |
| Nicole Burdette | Barbara Giglione |
| Ralph Lucarelli | Cozzerelli |
| Peter McRobbie | Father Felix |
| Sharon Angela | Rosalie Aprile |
| Jason Cerbone | Jackie Aprile Jr. |
| Tim Gallin | Joe Zachary |
| Marcia Haufrecht | Fanny |
| Maureen Van Zandt | Gabriella Dante |
| Vito Antuofermo | Bobby Zanone
(as Vito Antuofurmo Sr.) |
| Dimitri DeFresco | Drew
(as Dimitri De Fresco) |
| Marie Donato | 2 to 5 /
7 to 9 |
| Katalin Pota | Lilliana Wosilius |
| Ed Vassallo | Tom Giglione |
| Gary Evans | FBI Tech #2 |
| Frank Pando | Agent Grasso |
| Carlos Lopez | FBI Technician |
| Michael Strano | FBI Agent |
| Raymond Franza | Donny K.
(uncredited) |
| Gaetano LoGiudice | Guest at Wake
(uncredited) |