| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Nancy Marchand | Livia Soprano |
| John Ventimiglia | Artie Bucco |
| Kathrine Narducci | Charmaine Bucco
(as Katherine Narducci) |
| Frank Pellegrino | Agent Frank Cubitoso |
| Al Sapienza | Mikey Palmice |
| Paul Schulze | Father Phil Intintola |
| Drea de Matteo | Adriana La Cerva |
| Tony Darrow | Larry Boy Barese |
| George Loros | Raymond Curto |
| Joseph Badalucco Jr. | Jimmy Altieri
(as Joe Badalucco Jr.) |
| Sal Ruffino | Chucky Signore |
| Sharon Angela | Rosalie Aprile |
| John Aprea | U.S. Attorney |
| George Bass | Janitor |
| Gene Canfield | Police Officer |
| Frankie Dellarosa | EMT
(as Frank Dellarosa) |
| Douglas Santiago | Jeremy Herrera
(as Santiago Douglas) |
| Militza Ivanova | Russian Woman |
| Frank Pando | Agent Grasso |
| Annika Pergament | Newscaster |
| Michele Santopietro | JoJo Palmice |
| Matt Servitto | Agent Dwight Harris |
| Candy Trabuco | Ms. Giaculo
(as Candy Trabucco) |
| Robert LuPone | Dr. Bruce Cusamano
(uncredited) |
| Peter Austin Noto | Tony's Friend
(uncredited) |
| Joe Pucillo | Beppy Scerbo
(uncredited) |
| Saundra Santiago | Jean Cusamano
(uncredited) |