| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| David Zayas | Lt. Angel Batista |
| Aimee Garcia | Jamie Batista |
| Geoff Pierson | Deputy Chief Tom Matthews |
| James Remar | Harry Morgan
(credit only) |
| Charlotte Rampling | Dr. Evelyn Vogel |
| Sean Patrick Flanery | Jacob Elway |
| Rebecca Staab | Lucy Gerard |
| Jadon Wells | Harrison Morgan |
| Dana L. Wilson | Det. Angie Miller |
| Scott Michael Morgan | Sussman |
| Andrew Elvis Miller | Ron Galuzzo |
| Kurt Caceres | Officer Martinez |
| Christine Garver | Young Waitress |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Tawny Amber Young | Cheating Secretary
(uncredited) |