| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| David Zayas | Lt. Angel Batista |
| Aimee Garcia | Jamie Batista |
| Geoff Pierson | Deputy Chief Tom Matthews |
| James Remar | Harry Morgan |
| Charlotte Rampling | Dr. Evelyn Vogel |
| Sean Patrick Flanery | Jacob Elway |
| Rhys Coiro | Andrew Briggs |
| Jadon Wells | Harrison Morgan |
| Dana L. Wilson | Det. Angie Miller |
| Nick Gomez | Javier 'El Sapo' Guzman |
| Nadège August | Receptionist |
| Jennifer Christopher | Fort Lauderdale Police Officer |
| Lewis T. Powell | Driver |
| Britt George | Beaten Man
(uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Victoria Vertuga | Hot Soccer Mom
(uncredited) |