| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Capt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| Yvonne Strahovski | Hannah McKay |
| Erik King | Sgt. James Doakes |
| Geoff Pierson | Tom Matthews |
| Aimee Garcia | Jamie Batista |
| Nestor Serrano | Hector Estrada |
| Nicole LaLiberte | Arlene Schram
(as Nicole Laliberte) |
| Luke Andrew Kruntchev | Harrison Morgan |
| Francisco Viana | Det. Jake Simms |
| Dana L. Wilson | Det. Angie Miller |
| A.J. Castro | First Deputy |
| Ariel Llinas | Second Deputy |
| Patrick Robert Smith | Bailiff |
| Oliver Vaquer | Attorney |
| Peggy Blow | Florencia Estrada
(as Peggy Ann Blow) |
| Amy Correa | Maracas Woman
(as Amy Correa Bell) |
| Jared Farid Ward | Barnes
(as Jared Ward) |
| Wendy Haines | Nurse |
| Billy Joe Brewer III | Reveler
(uncredited) |
| Marisa Hamamoto | Salsa Dancer
(uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Sexton Newby | Prison Guard
(uncredited) |