| Kiefer Sutherland | Tom Kirkman |
| Natascha McElhone | Alex Kirkman |
| Adan Canto | Aaron Shore |
| Italia Ricci | Emily Rhodes |
| LaMonica Garrett | Mike Ritter |
| Kal Penn | Seth Wright |
| Maggie Q | Hannah Wells |
| Rob Morrow | Abe Leonard |
| Reed Diamond | John Forstell |
| Terry Serpico | Patrick Lloyd |
| Romina D'Ugo | Lucy Fernandez |
| Geoff Pierson | Cornelius Moss |
| Zorana Sadiq | Alyssa Abboud |
| Peggy Lee | Anchor |
| George Tchortov | Catalan (Nestor Lozano) |
| Jake Epstein | Chuck Russink |
| Al McFoster | FBI Agent #1 |
| Cameron Skura | FBI Tactical Agent |
| Guy Buller | German Chancellor Jonas Grottke |
| Desmond Campbell | HRT Agent |
| Bayley Ungurain | Janet |
| Richard Waugh | Jay Whitaker |
| Mathieu Bourassa | Lead HRT Agent |
| Scott Schaffer | Morning Show Host |
| Mercedes de la Zerda | Nadia Espinosa |
| Sophia Walker | Olivia Abram |
| George Kelebay | Polish President Borys Godek |
| Vieslav Krystyan | Slovakian President Josef Kovacs |
| Sonia Dhillon Tully | British Prime Minister Aruna Mahajan |
| Jocelyne Zucco | French Prime Minister Justine Massett |
| Dwight Ireland | Reporter |
| Dan Duran | Reporter Joel Estevez |
| Alejandro Alvarez Cadilla | Spanish Reporter |
| Allison Feliciano | Staffer Janine |
| Jesse Griffiths | Staffer Rob |
| Dipal Patel | Staffer Tim |
| John Chou | Victor Kim |
| Andrew Martin Priestman | HRT |
| Velva Nystrom | NATO Leader |
| Michael Sercerchi | US Presidential Aide |
| Sylvia Zuk | Lithuanian Minister |