| Timothy Olyphant | Seth Bullock |
| Ian McShane | Al Swearengen |
| Molly Parker | Alma Garret |
| Jim Beaver | Whitney Ellsworth |
| W. Earl Brown | Dan Dority |
| Kim Dickens | Joanie Stubbs |
| Brad Dourif | Doc Cochran |
| Anna Gunn | Martha Bullock |
| John Hawkes | Sol Star |
| Jeffrey Jones | A.W. Merrick
(credit only) |
| Paula Malcomson | Trixie |
| Leon Rippy | Tom Nuttall
(credit only) |
| William Sanderson | E.B. Farnum |
| Robin Weigert | Calamity Jane |
| Dayton Callie | Charlie Utter |
| Sean Bridgers | Johnny Burns |
| Garret Dillahunt | Francis Wolcott |
| Titus Welliver | Silas Adams
(credit only) |
| Bree Seanna Wall | Sofia Metz |
| Josh Eriksson | William Bullock |
| Powers Boothe | Cy Tolliver |
| Alice Krige | Maddie |
| Sarah Paulson | Miss Isringhausen |
| Keone Young | Mr. Wu |
| Geri Jewell | Jewel |
| Peter Jason | Con Stapleton |
| Larry Cedar | Leon |
| Nick Amandos | Jack - Bella Union Bartender |
| Holly Carbrey | |
| Fiona Dourif | Chez Ami Whore |
| Meghan Glennon | Lila |
| Gary Leffew | Vigilante |
| Chandra Richards | Rose |
| Ralph Richeson | Richardson |
| Damon Weber | Oregon Bound Boy |
| Parisse Boothe | Tess
(uncredited) |