| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jeanne Tripplehorn | Alex Blake |
| Thomas Gibson | Aaron Hotchner |
| Rochelle Aytes | Savannah Hayes |
| Anne Leighton | Sheila Harrison |
| Marshall R. Teague | Dr. Edward Calder
(as Marshall Teague) |
| Jason Turner | Dr. Albert Miles |
| Lisa Grady | Agnes Kane |
| CJ McBath | Marcus Kinman |
| Colleen Donovan | Christy White |
| Alisha Wainwright | Debbie Martin |
| Dwight Hicks | Raymond Martin |
| Matthew Helfer | Trevor Burkett |
| Luke Loving | Adam Richmond |
| Ty LaPlaunt | Christopher Stafford |
| Ella Schaefer | Lauryn-Anne Harrison
(as Elly Schaefer) |
| Mark Vuncannon | Hunter |
| Dar Dixon | Michael Smith |
| Steve Wong | FBI Agent Car
(uncredited) |