| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jeanne Tripplehorn | Alex Blake |
| Thomas Gibson | Aaron Hotchner |
| Frederick Koehler | Wallace Hines /
Jesse Gentry
(as Fred Koehler) |
| Camryn Manheim | Carla Hines |
| JoNell Kennedy | Sgt. Lynne Johnson |
| Brianne Howey | Heather Clarke |
| John Michael Herndon | Bill Robbins |
| Douglas Olsson | Mark Anderson |
| Dominique Razon | Elizabeth Nash
(as Dominique Razón) |
| Stephanie Nash | Jean Clarke |
| Richard Gleason | Bob Clarke |
| Joseph Baird | Danny Randall |
| Elizabeth Schmidt | Vanessa Randall |
| Gene Rathswohl | Officer Bachner |
| Bill Blair | Jesse's Adoptive Dad
(uncredited) |
| Kyle Cartieri | Paralegal
(uncredited) |
| Jeremy Cohenour | Wallace /
Jesse
(uncredited) |
| Kayla Drew | Young Heather
(uncredited) |
| Bryan Stamp | Train Station Employee
(uncredited) |