| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| Adam Nelson | Thomas Yates |
| René Ashton | Grace Powell |
| Cyndi Martino | Diane |
| Denise Carole | Crystal |
| Zack Weinstein | David Zimmerman |
| Ashley Leggat | Sloan |
| Kai Paynter | Bianca
(as Kagiso Alicia Paynter) |
| Sally Hughes | Devin |
| Nate Thomas | Lance |
| Elizabeth June | Prof. Marsha Grant |
| Daniel Guzman | Dr. Castro |
| Eileen Fogarty | Dr. Lin |
| Kay D'Arcy | Trudy Yates (2009) |
| Kelly Lynn Warren | Trudy Yates (1977) |
| Tara Shayne | Tina Dyson |
| Kellen McGee | Angie |
| Julie Dove | Brianne Matloff |
| Alec Gatlin | 10-year-old Tommy Yates |
| Tom Phelan | 15 Year Old Tommy Yates |
| Elizabeth Southard | Becca |
| Eugenia Care | Marie |
| Linda Larson | Lynn
(as Linda Sandee Larson) |
| Paul Morgan Fredrix | Donald |
| Richard Henning | John |
| Shannon Sullivan | Ruth Thomas |
| Dan Hewitt Owens | Steve
(as Dan Owens) |
| Jolie Adamson | Georgina Yates |
| Elan Goldstein | College Student
(uncredited) |
| Stephen Janousek | College Student
(uncredited) |
| Amor Sanchez | Mug Shot
(uncredited) |