| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| Dean Cain | Curtis Banks |
| Joe Egender | Eddie Langdon |
| Vanessa Branch | Teri Banks |
| Nicholas Brendon | Kevin Lynch |
| Sandra Purpuro | Agent Carol Goslin |
| Frankie J. Allison | Vince Rebetti
(as Frankie Jay Allison) |
| Jenn Korbee | Francesca |
| Chuck Saale | Head of Security |
| Christopher DeMaci | Jimmy |
| Randy Irwin | Security Guard |
| Yanni Walker | Player #1 |
| Chasty Ballesteros | Tahitian Girl |
| Nikki Ganz | Liz Dorsey |
| Stewart Strauss | Poker Dealer
(uncredited) |
| Tim Womack | Casino Security
(uncredited) |