| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| Max Martini | Luke Dolan |
| Sarah Aldrich | Jenna Dolan |
| Michael Bofshever | Mark Dolan |
| Janice Kent | Wendy Milgram |
| Lindsey Ginter | General Boyd Milgram |
| Rodney J. Hobbs | State Trooper Brian Long |
| Bruno Amato | HRT Commander Powell |
| Jamie Silberhartz | Jamie |
| Robert Steinman Elden | Carter Tadman
(as Robert Steinman) |
| Hana Hayes | Ally Dolan |
| Bryan Friday | Adam Werner |
| Andy S. Allen | Nathan Muntz
(as Andy Allen) |
| Robin Dale Meyers | Dr. Risa Coletti
(as Robin Daléa) |
| Vince Green | Uniformed Officer |
| Gina St. John | Reporter |
| Julia Rhoda | Mary Dolan |
| Andre Ellington | Driver |
| Andre G. Ellingson | Man in Van |
| Sean Hemeon | Police Officer
(uncredited) |