| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| Daniel J. Travanti | Lee Mullens |
| Josh Braaten | Colby Bachner |
| David Rees Snell | Detective Green |
| Michael Spound | Sam DeLilly |
| Mary Beth Evans | Candice DeLilly |
| Josh Woodle | Michael Young |
| Cristen Irene | Anna |
| Ellie Gerber | Heather Langley |
| Renato Powell | Jocelyn Sherman |
| Marissa Skell | Shelly |
| Heather Simpson | Karen Bachner |
| Shaun Russell | Prison Guard
(as T. Shaun Russell) |
| Michael Lespinasse | Officer
(as Michael Lesly) |
| Megan Gallacher | Jenny DeLilly |
| Mateus Ward | Lyle DeLilly |
| Michael Ketzner | Young Colby |
| Laura Hunter Drago | Pharmacy Customer
(as Laura Hunter) |
| Mark Hutter | Mr. Langley |
| Ashley Morgan Kilbride | Blonde Victim |
| Nan McNamara | Mrs. Langley
(uncredited) |