| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| William Sadler | Ray Finnegan |
| Lawrence Pressman | Judge Schuller |
| Vincent Guastaferro | Det. Gil Hardesty |
| Cynthia Watros | Heather Vanderwaal |
| D.B. Sweeney | U.S. Marshal Sam Kassmeyer |
| Leith M. Burke | Jerry Sorum
(as Leith Burke) |
| Cliff Weissman | Drew Sandweiss |
| Tom Ohmer | Bosola |
| Glenn Keogh | Sean |
| Dale Waddington | Medical Examiner
(as Dale Waddington Horowitz) |
| Mahryah Shain | Dan Patton |
| Aisha Kabia | Reporter |
| Hannah Brylowe | Allison Sandweiss |
| Cade Owens | Jack Hotchner |
| Angie Kibiloski | ND Detective |
| Amy E. Koppelman | U.S. Marshal
(uncredited) |